Przewidywanie ciężkości COVID-19

• Julian
• 30 kwietnia, 202130 kwietnia, 2021
• 0

Przewidywanie ciężkości COVID-19 za pomocą swoistego przeciwciała nukleokapsydowego i wskaźnika czynnika ryzyka choroby 

Efficient strategies for predicting COVID-19 illness trajectories are urgently wanted. Right here, enzyme-linked immunosorbent assay (ELISA) and coronavirus antigen microarray (COVAM) evaluation mapped antibody epitopes within the plasma of COVID-19 sufferers (n = 86) experiencing a variety of illness states. The experiments recognized antibodies to a 21-residue epitope from nucleocapsid (termed Ep9) related to extreme illness, together with admission to the intensive care unit (ICU), requirement for ventilators, or demise.

Importantly, anti-Ep9 antibodies will be detected inside 6 days post-symptom onset and generally inside 1 day. Moreover, anti-Ep9 antibodies correlate with varied comorbidities and hallmarks of immune hyperactivity. We introduce a simple-to-calculate, illness threat issue rating to quantitate every affected person’s comorbidities and age. For sufferers with anti-Ep9 antibodies, scores above 3.Zero predict extra extreme illness outcomes with a 13.42 chance ratio (96.7% specificity).

The outcomes lay the groundwork for a brand new sort of COVID-19 prognostic to permit early identification and triage of high-risk sufferers. Such info might information more practical therapeutic intervention.IMPORTANCE The COVID-19 pandemic has resulted in over two million deaths worldwide. Regardless of efforts to struggle the virus, the illness continues to overwhelm hospitals with severely unwell sufferers.

Prognosis of COVID-19 is instantly completed by a mess of dependable testing platforms; nonetheless, prognostic prediction stays elusive. To this finish, we recognized a brief epitope from the SARS-CoV-2 nucleocapsid protein and likewise a illness threat issue rating primarily based upon comorbidities and age. The presence of antibodies particularly binding to this epitope plus a rating cutoff can predict extreme COVID-19 outcomes with 96.7% specificity.

Anti-IGF-IIR antibody
STJ96634	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to IGF-IIR.

Anti-IGF-IR antibody
STJ98158	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to IGF-IR.

Anti-IGF-IR antibody
STJ98159	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to IGF-IR.

Anti-IGF-IR antibody
STJ93647	St John's Laboratory	200 µl	EUR 197
Description: IGF-IR is a protein encoded by the IGF1R gene which is approximately 154,7 kDa. IGF-IR is localised to the cell membrane. It is involved in apoptotic pathways, the GPCR pathway and ERK signalling. It is a receptor tyrosine kinase which mediates actions of insulin-like growth factor 1. The activated protein is involved in cell growth and survival control and is also crucial for tumour transformation and survival of malignant cells. It is formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IGF-IR is expressed in the nervous system, skin, pancreas, lung and muscle. Mutations in the IGF1R gene may result in insulin-like growth factor 1 resistance. STJ93647 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of IGF-IR protein.

Anti-IGF-IR antibody
STJ93648	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to IGF-IR.

Anti-IGF-I antibody
STJ93653	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to IGF-I.

Anti-IGF-IIR antibody
STJ93654	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to IGF-IIR.

Anti-IGF-IIR antibody
STJ93655	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to IGF-IIR.

Anti-IGF-IR antibody
STJ93656	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to IGF-IR.

Anti-IGF-IR antibody
STJ93657	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to IGF-IR.

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 280

anti-IGF-1R (Ab-1280)
LF-PA20229	Abfrontier	100 ul	EUR 334
Description: Rabbit polyclonal to IGF-1R

anti-IGF-1R (Ab-1346)
LF-PA20230	Abfrontier	100 ul	EUR 334
Description: Rabbit polyclonal to IGF-1R

anti-IGF-1R (Ab-1161)
LF-PA20231	Abfrontier	100 ul	EUR 334
Description: Rabbit polyclonal to IGF-1R

anti-IGF-1R (Phospho-Tyr1161)
LF-PA20233	Abfrontier	100 ul	EUR 354
Description: Rabbit polyclonal to IGF-1R (Phospho-Tyr1161)

Anti-Rat IGF-1 Antibody
5121-100	Biovision		EUR 316

Anti-Rat IGF-1 Antibody
5121-30T	Biovision		EUR 146

Human Salivary IGF(salivary IGF) ELISA Kit
QY-E05383	Qayee Biotechnology	96T	EUR 361

Anti-IGF-1R (Teprotumumab), Human IgG1 Antibody
A2160-100	Biovision	100 µg	EUR 510

IGF-1, human
RC216-12	Bio Basic	1mg	EUR 376.25

IGF-BP3, human
RC216-12B3	Bio Basic	5ug	EUR 104.38

IGF-1, Human
HY-P7018	MedChemExpress	10ug	EUR 108

IGF-2, Human
HY-P7019	MedChemExpress	100ug	EUR 360

IGF-BP3, Human
HY-P7020	MedChemExpress	10ug	EUR 234

IGF-BP5, Human
HY-P7021	MedChemExpress	50ug	EUR 601

Polyclonal Anti-Rat IGF-1 Antibody
APR00269G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Anti-Rat IGF-1 . This antibody is tested and proven to work in the following applications:

Anti-IGF-1R (Ab-1161) Antibody
A00070-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal IGF-1R (Ab-1161) Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Phospho-IGF-IR (Y1346) antibody
STJ91187	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Phospho-IGF-IR (Y1346).

Anti-Phospho-IGF-IR (Y1161) antibody
STJ90298	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Phospho-IGF-IR (Y1161).

Anti-Phospho-IGF-IIR (S2409) antibody
STJ90923	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Phospho-IGF-IIR (S2409).

Anti-Phospho-IGF-IR (Y1161) antibody
STJ91026	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Phospho-IGF-IR (Y1161).

anti-IGF-1R (Ab-1165/1166)
LF-PA20232	Abfrontier	100 ul	EUR 334
Description: Rabbit polyclonal to IGF-1R

anti-IGF-1R (Phospho-Tyr1165/Tyr1166)
LF-PA20234	Abfrontier	100 ul	EUR 354
Description: Rabbit polyclonal to IGF-1R (Phospho-Tyr1165/Tyr1166)

IGF-II
PR15045CF	Neuromics	50 ug	EUR 278

Human [Arg6] IGF-II
GU020	GroPep	20 µg	EUR 253

Human [Leu24] IGF-I
ZU020	GroPep	20 µg	EUR 253

Human [Leu24] IGF-I
ZU100	GroPep	100 µg	EUR 346

Human [Leu27]IGF-II
TU100	GroPep	100 µg	EUR 346

Biotinyl Human IGF-I
AQU010	GroPep	10 µg	EUR 253

Biotinyl Human IGF-I
AQU050	GroPep	50 µg	EUR 346

Biotinyl Human IGF-I
AQU100	GroPep	100 µg	EUR 531

Biotinyl Human IGF-I
AQU500	GroPep	500 µg	EUR 1088

Human [Ala31] IGF-I
AIU020	GroPep	20 µg	EUR 253

Human [Ala31] IGF-I
AIU100	GroPep	100 µg	EUR 346

Human IGF-I Protein
abx060791-100ug	Abbexa	100 ug	EUR 467

Human [Leu60] IGF-I
ABU020	GroPep	20 µg	EUR 253

Human [Leu60] IGF-I
ABU100	GroPep	100 µg	EUR 346

Human IGF-1 LR3
SP-89927-100	Alpha Diagnostics	100 ug	EUR 225

IGF-1, human recombinant
P1016-.02	ApexBio	20 µg	EUR 258
Description: Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue

IGF-1, human recombinant
P1016-.1	ApexBio	100 µg	EUR 763
Description: Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue

IGF-II, human recombinant
P1017-.01	ApexBio	10 µg	EUR 161
Description: Insulin-like Growth Factor-II (IGF-II) is a polypeptide endocrine hormone structurally similar to insulin and belongs to insulin-like growth factor family.

IGF-II, human recombinant
P1017-.05	ApexBio	50 µg	EUR 313
Description: Insulin-like Growth Factor-II (IGF-II) is a polypeptide endocrine hormone structurally similar to insulin and belongs to insulin-like growth factor family.

IGF-II, human recombinant
P1017-1	ApexBio	1 mg	EUR 1998
Description: Insulin-like Growth Factor-II (IGF-II) is a polypeptide endocrine hormone structurally similar to insulin and belongs to insulin-like growth factor family.

rec IGF-I (human)
H-5555.0050	Bachem	50.0µg	EUR 242
Description: CAS# [67763-96-6]

rec IGF-I (human)
H-5555.0100	Bachem	100.0µg	EUR 381
Description: CAS# [67763-96-6]

rec IGF-I (human)
H-5555.0500	Bachem	0.5mg	EUR 1434
Description: CAS# [67763-96-6]

IGF-I, human recombinant
4119-100	Biovision		EUR 175

IGF-I, human recombinant
4119-1000	Biovision		EUR 343

IGF-I, human recombinant
4119-10MG	Biovision		EUR 1529

IGF-I, human recombinant
4119-1G	Biovision		EUR 41157

IGF-I, human recombinant
4119-20MG	Biovision		EUR 2328

IGF-I, human recombinant
4119-5000	Biovision		EUR 958

IGF-I, human recombinant
4119-50MG	Biovision		EUR 4220

IGF-II, human recombinant
4122-10	Biovision		EUR 137

IGF-II, human recombinant
4122-1000	Biovision		EUR 1572

IGF-II, human recombinant
4122-50	Biovision		EUR 256

IGF-BP1, human recombinant
4717-100	Biovision		EUR 620

IGF-BP1, human recombinant
4717-1000	Biovision		EUR 3149

IGF-BP1, human recombinant
4717-25	Biovision		EUR 256

IGF-BP3, human recombinant
4720-100	Biovision		EUR 620

IGF-BP3, human recombinant
4720-1000	Biovision		EUR 3149

IGF-BP3, human recombinant
4720-25	Biovision		EUR 256

IGF-BP5, human recombinant
4723-100	Biovision		EUR 620

IGF-BP5, human recombinant
4723-1000	Biovision		EUR 3149

IGF-BP5, human recombinant
4723-25	Biovision		EUR 256

IGF-BP2, human recombinant
7165-10	Biovision		EUR 251

IGF-BP2, human recombinant
7165-50	Biovision		EUR 936

IGF-BP7, human recombinant
7167-10	Biovision		EUR 207

IGF-BP7, human recombinant
7167-50	Biovision		EUR 675

IGF-BP6, human recombinant
7350-20	Biovision		EUR 370

IGF-2/ Rat IGF- 2 ELISA Kit
ELA-E0051r	Lifescience Market	96 Tests	EUR 886

Anti-IGF1/Igf I Rabbit Monoclonal Antibody
M00148	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal IGF1/Igf I Antibody. Validated in WB and tested in Human.

Anti-IGF2/Igf Ii Rabbit Monoclonal Antibody
M00335	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal IGF2/Igf Ii Antibody. Validated in IF, WB and tested in Human.

Anti-Phospho-IGF-IR (Y1165/Y1166) antibody
STJ90299	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Phospho-IGF-IR (Y1165/Y1166).

Mouse Anti-Human IGF-1R monoclonal antibody, clone JID716
CABT-L2807-100uL500uL	Creative Diagnostics	100 uL, 500 uL	EUR 502

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-100ug
QP5264-100ug	EnQuireBio	100ug	EUR 363

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-10ug
QP5264-10ug	EnQuireBio	10ug	EUR 136

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-1mg
QP5264-1mg	EnQuireBio	1mg	EUR 1261

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-500ug
QP5264-500ug	EnQuireBio	500ug	EUR 762

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-50ug
QP5264-50ug	EnQuireBio	50ug	EUR 237

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-100ug
QP8601-ec-100ug	EnQuireBio	100ug	EUR 408

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-10ug
QP8601-ec-10ug	EnQuireBio	10ug	EUR 200

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-1mg
QP8601-ec-1mg	EnQuireBio	1mg	EUR 1632

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-200ug
QP8601-ec-200ug	EnQuireBio	200ug	EUR 634

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-500ug
QP8601-ec-500ug	EnQuireBio	500ug	EUR 1060

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-50ug
QP8601-ec-50ug	EnQuireBio	50ug	EUR 263

Recombinant Human IGF-BP7 Protein
PROTQ16270-2	BosterBio	25ug	EUR 317
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP7 is expressed in a wide range of normal human tissues and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. It plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. Recombinant human IGF-BP7 is a 26.4 kDa protein consisting of 256 amino acid residues.

Human IGF-I monoclonal antibody
MAM1	GroPep	500 µg	EUR 299

Human IGF-II (Media Grade)
OM001	GroPep	1 mg	EUR 902

Human IGF-II (Media Grade)
OU100	GroPep	100 µg	EUR 327

Human IGF-II (Receptor Grade)
FM001	GroPep	1 mg	EUR 161

Human IGF-II (Receptor Grade)
FU020	GroPep	20 µg	EUR 299

Human IGF-II (Receptor Grade)
FU100	GroPep	100 µg	EUR 392

Recombinant Human IGF-II Protein
PROTP01344-1	BosterBio	50ug	EUR 317
Description: The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.

Recombinant Human IGF-I Protein
PROTP05019-1	BosterBio	500ug	EUR 317
Description: The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.

Recombinant Human IGF-BP1 Protein
PROTP08833-1	BosterBio	25ug	EUR 317
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, deciduas, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds to both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, where as nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a 25.4 kDa protein consisting of 235 amino acid residues (Isoform A).

Recombinant Human IGF-BP3 Protein
PROTP17936-2	BosterBio	25ug	EUR 317
Description: IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.

Recombinant Human IGF-BP2 Protein
PROTP18065	BosterBio	20ug	EUR 317
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. *Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Związek między poziomami alarmin w surowicy a wskaźnikami specyficznymi dla choroby u pacjentów z zapaleniem naczyń związanym z cytoplazmatycznymi przeciwciałami przeciw neutrofilom 

Background/purpose: We evaluated the connection between serum alarmin ranges and disease-specific indices in sufferers with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Sufferers and strategies: Sera and information from 79 sufferers had been utilized. For AAV-specific indices, Birmingham vasculitis exercise rating (BVAS), five-factor rating (FFS), and vasculitis harm index (VDI) had been collected and serum ranges of 4 alarmins (hepatoma-derived progress issue, excessive mobility group field protein 1, S100A9, and S100A12) had been measured utilizing enzyme-linked immunosorbent assay. Associations between alarmin ranges, AAV-specific indices, and inflammatory laboratory markers had been assessed.

Outcomes: S100A9 ranges had been considerably correlated with C-reactive protein ranges (r=0.316, p=0.005) and S100A12 ranges correlated with VDI (r=0.232, p=0.040), which was constant in a subgroup of sufferers with myeloperoxidase (perinuclear)-ANCA positivity. No different associations had been discovered between alarmin ranges and BVAS, FFS, and VDI.

Conclusion: The serum S100A12 degree was related to organ harm in AAV, particularly in myeloperoxidase (perinuclear)-ANCA-positive sufferers.

Zapalenie skórno-mięśniowe z dodatnim przeciwciałem anty-MDA5 z szybko postępującą śródmiąższową chorobą płuc: opis dwóch przypadków

 Melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (DM) shows distinctive cutaneous and pathologic options. We describe two circumstances of myositis-associated quickly progressive interstitial lung illness (RP-ILD).

The sufferers had been two girls from Kerala, India. Each sufferers had anti-MDA5 antibody-positive myositis. Each sufferers offered with RP-ILD with none scientific options of myositis and succumbed to their sickness regardless of aggressive medical therapy. Anti-MDA5-antibody-positive DM is characterised by amyopathic illness with quickly progressive and deadly ILD.

Charakterystyka przeciwciał monoklonalnych przeciw tężcowi jako pierwszy krok w kierunku opracowania testu immunologicznego na siłę szczepionki in vitro 

Batch launch testing for human and veterinary tetanus vaccines nonetheless depends closely on strategies that contain animals, notably for efficiency testing. The amount and high quality of tetanus antigen current in these merchandise is of utmost significance for product security and scientific impact. Immunochemical strategies that measure consistency of antigen content material and high quality, doubtlessly as an indicator of efficiency, may very well be a better option and negate the necessity for an in vivo efficiency check. These immunochemical strategies require at the least one nicely characterised monoclonal antibody (mAb) that’s particular for the goal antigen. On this paper we report the outcomes of the excellent characterisation of a panel of mAbs towards tetanus with a view to pick antibodies that can be utilized for improvement of an in vitro efficiency immunoassay.

We’ve assessed binding of the antibodies to native antigen (toxin), detoxified antigen (toxoid), adsorbed antigen and heat-altered antigen. Antibody perform was decided utilizing an in-house cell-based neutralisation assay to assist prior in vivo efficiency information that was obtainable for some, however not all, of the antibodies. As well as, antibody affinity was measured, and epitope competitors evaluation was carried out to establish pairs of antibodies that may very well be deployed in a sandwich immunoassay format. Not all characterisation assessments offered proof of “superiority” of 1 mAb over one other, however collectively the outcomes from all characterisation research allowed for choice of an antibody pair to be taken ahead to assay improvement.

Opis przypadku: autoimmunologiczne zapalenie mózgu związane z przeciwciałami dekarboksylazy kwasu przeciwglutaminowego: seria przypadków pediatrycznych

Background: Antibodies towards glutamic acid decarboxylase (GAD) are related to varied neurologic circumstances described in sufferers, together with stiff particular person syndrome, cerebellar ataxia, refractory epilepsy, and limbic and extralimbic encephalitis. There have been some case stories and investigations relating to anti-GAD65 antibody-associated encephalitis in grownup populations, however pediatric circumstances are uncommon. We retrospectively analyzed the scientific information of three anti-GAD65 antibody-positive sufferers to discover the range and scientific options of anti-GAD65 antibody-associated pediatric autoimmune encephalitis.

Strategies: The scientific information of a sequence of three sufferers optimistic for anti-GAD65 antibody had been retrospectively analyzed. GAD65 antibodies had been decided in serum and CSF utilizing a cell-based assay.

Outcomes: All three sufferers had been feminine, and the onset ages had been four years and 9 months, 6 years, and 16 years previous. Their scientific phenotypes included autoimmune limbic encephalitis, extralimbic encephalitis, and encephalitis combining limbic and extralimbic encephalitis. The scientific signs included seizures, reminiscence deficits, drowsiness, dysautonomia, and headache. All sufferers had irregular carinal MRI and EEG. All sufferers obtained immunotherapy and had transiently good responsiveness, however one affected person then skilled relapse. In follow-up, one affected person with extralimbic encephalitis recovered utterly, whereas two sufferers with limbic involvement had poor outcomes with refractory focal epilepsy.

Conclusion: Along with limbic encephalitis, extralimbic encephalitis can also be an necessary phenotype in sufferers who’re optimistic for anti-GAD65 antibodies. Early analysis and immunotherapy can enhance the signs. Nevertheless, sufferers with limbic encephalitis typically have refractory epilepsy within the continual section and have a poor long-term final result.

NAP-2, CXCL7, human
RC312-18	Bio Basic	2ug	EUR 104.38

NAP-2, CXCL7, rat
RC352-18	Bio Basic	2ug	EUR 104.38

NAP-2/CXCL7, Human
HY-P7268	MedChemExpress	50ug	EUR 533

NAP-2/CXCL7, Rat
HY-P7269	MedChemExpress	50ug	EUR 533

CXCL7 ELISA KIT|Human
EF001450	Lifescience Market	96 Tests	EUR 689

Human CXCL7 ELISA Kit
LF-EK50893	Abfrontier	1×96T	EUR 648

Mouse beta Thromboglobulin (CXCL7/bTG) CLIA Kit
20-abx491403	Abbexa	EUR 7973.00 EUR 4246.00 EUR 981.00	10 × 96 tests 5 × 96 tests 96 tests

Human CXCL7 PicoKine ELISA Kit
EK0729	BosterBio	96 wells	EUR 425
Description: For quantitative detection of human CXCL7 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human CXCL7 Antibody (Biotin Conjugate)
32852-05121	AssayPro	150 ug	EUR 369

Human CXCL7 AssayMax ELISA Kit
EC2270-1	AssayPro	96 Well Plate	EUR 477

ELISA kit for Human CXCL7
EK5304	SAB	96 tests	EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CXCL7 in samples from serum, plasma, tissue homogenates and other biological fluids.

Recombinant Human CXCL7/NAP-2 Protein
RP00829	Abclonal	10 μg	EUR 221

NAP-2/CXCL7 (CHO-expressed), Human
HY-P7267	MedChemExpress	50ug	EUR 497

ThymusChemokine‑1/CXCL7 (CHO-expressed), Rat
HY-P7301	MedChemExpress	10ug	EUR 291

Rat PPBP/CXCL7 PicoKine ELISA Kit
EK0731	BosterBio	96 wells	EUR 425
Description: For Quantitative Detection of rat CXCL7 in cell culture supernates, serum and plasma (heparin, EDTA).

Human CXCL7 AssayLite Antibody (FITC Conjugate)
32852-05141	AssayPro	150 ug	EUR 428

Human CXCL7 AssayLite Antibody (RPE Conjugate)
32852-05151	AssayPro	150 ug	EUR 428

Human CXCL7 AssayLite Antibody (APC Conjugate)
32852-05161	AssayPro	150 ug	EUR 428

Human CXCL7 AssayLite Antibody (PerCP Conjugate)
32852-05171	AssayPro	150 ug	EUR 471

Neutrophil Activating Protein-2 (CXCL7) Antibody
20-abx137035	Abbexa	EUR 356.00 EUR 523.00	0.5 mg 1 mg

Neutrophil Activating Protein-2 (CXCL7) Protein
20-abx261559	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg

Neutrophil Activating Protein-2 (CXCL7) Protein
20-abx261561	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg

Nori® Hamster CXCL7 ELISA Kit
GR172274	Genorise Scientific	96-well	EUR 461

Nori Equine CXCL7/NAP2 ELISA Kit
GR106909	Genorise Scientific	96-well	EUR 461

Nori® Canine CXCL7 ELISA Kit
GR115398	Genorise Scientific	96-well	EUR 461

ELISA kit for Mouse ?TG/PBP/CXCL7/NAP2 (Thromboglobulin, Beta)
E-EL-M1269	Elabscience Biotech	1 plate of 96 wells	EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse ?TG/PBP/CXCL7/NAP2 (Thromboglobulin, Beta) in samples from Serum, Plasma, Cell supernatant

Recombinant Human Neutrophil Activating Protein-2 (CXCL7)
7-02059	CHI Scientific	2µg	Ask for price

Recombinant Human Neutrophil Activating Protein-2 (CXCL7)
7-02060	CHI Scientific	10µg	Ask for price

Recombinant Human Neutrophil Activating Protein-2 (CXCL7)
7-02061	CHI Scientific	1mg	Ask for price

Recombinant Rat Neutrophil Activating Protein-2 (CXCL7)
7-02065	CHI Scientific	2µg	Ask for price

Recombinant Rat Neutrophil Activating Protein-2 (CXCL7)
7-02066	CHI Scientific	10µg	Ask for price

Recombinant Rat Neutrophil Activating Protein-2 (CXCL7)
7-02067	CHI Scientific	1mg	Ask for price

Human CXCL7(Platelet basic protein) ELISA Kit
EH0007	FN Test	96T	EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Nori® Human CXCL7-NAP2 ELISA Kit
GR106282	Genorise Scientific	96-well	EUR 461

Pig Platelet Basic Protein / CXCL7 (PPBP) ELISA Kit
abx511493-96tests	Abbexa	96 tests	EUR 911

Neutrophil Activating Protein-2 (CXCL7), 95 a.a. Protein
20-abx260678	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg

Human Platelet Basic Protein / CXCL7 (PPBP) ELISA Kit
abx252283-96tests	Abbexa	96 tests	EUR 668

Rat Platelet Basic Protein / CXCL7 (PPBP) ELISA Kit
abx255841-96tests	Abbexa	96 tests	EUR 668

Recombinant (E.Coli) Human Neutrophil Activating Protein-2 (CXCL7)
RP-1008	Alpha Diagnostics	10 ug	EUR 286

Recombinant Human Neutrophil Activating Protein-2 (CXCL7), 95 a.a.
7-02062	CHI Scientific	2µg	Ask for price

Recombinant Human Neutrophil Activating Protein-2 (CXCL7), 95 a.a.
7-02063	CHI Scientific	10µg	Ask for price

Recombinant Human Neutrophil Activating Protein-2 (CXCL7), 95 a.a.
7-02064	CHI Scientific	1mg	Ask for price

Human Thromboglobulin, Beta (bTG/PBP/CXCL7/NAP2) CLIA Kit
abx197774-96tests	Abbexa	96 tests	EUR 825

NAP-2 Neutrophil Activating Protein-2 Rat Recombinant Protein (CXCL7)
PROTQ99ME0	BosterBio	Regular: 10ug	EUR 317
Description: NAP-2 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 62 amino acids and having a molecular mass of 6.8kDa.;The NAP 2 is purified by proprietary chromatographic techniques.

Human CXCL7 EZ-Set™ ELISA Kit (DIY Antibody Pairs)
EZ0729	BosterBio	5 plates/kit	EUR 268
Description: For the development of sandwich ELISA kit to measure human CXCL7 in cell culture supernates, cell lysates, tissue homogenates, serum and plasma (heparin, EDTA).

ELISA kit for Human ?TG/PBP/CXCL7/NAP2 (Thromboglobulin, Beta)
E-EL-H1007	Elabscience Biotech	1 plate of 96 wells	EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human ?TG/PBP/CXCL7/NAP2 (Thromboglobulin, Beta) in samples from Plasma

NAP-2 Neutrophil Activating Protein-2 Human Recombinant Protein (CXCL7)
PROTP02775	BosterBio	Regular: 10ug	EUR 317
Description: Neutrophil Activating Protein-2 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 70 amino acids and having a molecular mass of 7609 Dalton. ;The NAP-2 is purified by proprietary chromatographic techniques.

ELISA kit for Rat ?TG/PBP/CXCL7/NAP2 (Thromboglobulin, Beta)
E-EL-R1087	Elabscience Biotech	1 plate of 96 wells	EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Rat ?TG/PBP/CXCL7/NAP2 (Thromboglobulin, Beta) in samples from Serum, Plasma, Cell supernatant

Recombinant Human NAP-2/ PPBP/ CXCL7 Protein, Untagged, E.coli-100ug
QP10212-ec-100ug	EnQuireBio	100ug	EUR 988

Recombinant Human NAP-2/ PPBP/ CXCL7 Protein, Untagged, E.coli-10ug
QP10212-ec-10ug	EnQuireBio	10ug	EUR 290

Recombinant Human NAP-2/ PPBP/ CXCL7 Protein, Untagged, E.coli-250ug
QP10212-ec-250ug	EnQuireBio	250ug	EUR 1731

Recombinant Human NAP-2/ PPBP/ CXCL7 Protein, Untagged, E.coli-2ug
QP10212-ec-2ug	EnQuireBio	2ug	EUR 154

Recombinant Rat NAP-2/ PPBP/ CXCL7 Protein, Untagged, E.coli-100ug
QP10285-ec-100ug	EnQuireBio	100ug	EUR 1178

Recombinant Rat NAP-2/ PPBP/ CXCL7 Protein, Untagged, E.coli-10ug
QP10285-ec-10ug	EnQuireBio	10ug	EUR 290

Recombinant Rat NAP-2/ PPBP/ CXCL7 Protein, Untagged, E.coli-250ug
QP10285-ec-250ug	EnQuireBio	250ug	EUR 2067

Recombinant Rat NAP-2/ PPBP/ CXCL7 Protein, Untagged, E.coli-2ug
QP10285-ec-2ug	EnQuireBio	2ug	EUR 154

Recombinant Human NAP-2/ PPBP/ CXCL7 Protein, GST, E.coli-100ug
QP8641-ec-100ug	EnQuireBio	100ug	EUR 408

Recombinant Human NAP-2/ PPBP/ CXCL7 Protein, GST, E.coli-10ug
QP8641-ec-10ug	EnQuireBio	10ug	EUR 200

Recombinant Human NAP-2/ PPBP/ CXCL7 Protein, GST, E.coli-1mg
QP8641-ec-1mg	EnQuireBio	1mg	EUR 1632

Recombinant Human NAP-2/ PPBP/ CXCL7 Protein, GST, E.coli-200ug
QP8641-ec-200ug	EnQuireBio	200ug	EUR 634

Recombinant Human NAP-2/ PPBP/ CXCL7 Protein, GST, E.coli-500ug
QP8641-ec-500ug	EnQuireBio	500ug	EUR 1060

Recombinant Human NAP-2/ PPBP/ CXCL7 Protein, GST, E.coli-50ug
QP8641-ec-50ug	EnQuireBio	50ug	EUR 263

Recombinant Human C-X-C Motif Chemokine 7/CXCL7/NAP-2
C056-10ug	Novoprotein	10ug	EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human C-X-C Motif Chemokine 7/CXCL7/NAP-2
C056-1mg	Novoprotein	1mg	EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human C-X-C Motif Chemokine 7/CXCL7/NAP-2
C056-500ug	Novoprotein	500ug	EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human C-X-C Motif Chemokine 7/CXCL7/NAP-2
C056-50ug	Novoprotein	50ug	EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

NAP-2-95 Neutrophil Activating Protein-2 (CXCL7) Human Recombinant Protein, 95 a.a.
PROTP02775-1	BosterBio	Regular: 10ug	EUR 317
Description: NAP 2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 95 amino acids (35-128) and having a molecular mass of 10.3 kDa.;The NAP 2 is purified by proprietary chromatographic techniques.

Mouse Anti-FcεRIα
MOFCeRIaAP(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaAP(V25)	ImmunoStep	25 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaB(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaB(V25)	ImmunoStep	25 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaCFB(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaCFB(V25)	ImmunoStep	25 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaF(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaF(V25)	ImmunoStep	25 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaF(V500)	ImmunoStep	500 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaPE(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaPE(V25)	ImmunoStep	25 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaPP(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaPP(V25)	ImmunoStep	25 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaPP55(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaPP55(V25)	ImmunoStep	25 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaPU(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-FcεRIα
MOFCeRIaPU(V500)	ImmunoStep	500 ug	EUR 50

Mouse Anti-IL2
MOIL2A(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-IL2
MOIL2A(V25)	ImmunoStep	25 ug	EUR 50

Mouse Anti-IL2
MOIL2B(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-IL2
MOIL2B(V25)	ImmunoStep	25 ug	EUR 50

Mouse Anti-IL2
MOIL2CFB(V100)	ImmunoStep	100 ug	EUR 50

Mouse Anti-IL2
MOIL2CFB(V25)	ImmunoStep	25 ug	EUR 50